Yeah, but if you want to drag the Constitution into it, doesn't that just mean that we'll end up with a 10th Amendment case in the Supreme Court? ("The powers not delegated to the United States by the Constitution, nor prohibited by it to the States, are reserved to the States respectively, or to the people. - Where does the Constitution delegate this power to the United States?)

I suspect an argument could (and will) also be made on the first clause of your quoted text, on the basis that a health insurance mandate is not "made in Pursuance of [the Constitution]", so the Supremacy Clause doesn't apply to it.